We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
When sugars guide axons: insights from heparan sulphate proteoglycan mutants.
- Authors
Jeong-Soo Lee; Chi-Bin Chien
- Abstract
Although there have previously been hints that heparan sulphate proteoglycans (HSPGs) are important for axon guidance, as they are for many other biological processes, there has been little in vivo evidence for interaction with known axon-guidance pathways. Genetic analyses of fly, mouse, nematode and zebrafish mutants now confirm the role of HSPGs in axon guidance and are beginning to show that they might have a key role in modulating the action of axon-guidance ligands and receptors.
- Publication
Nature Reviews Genetics, 2004, Vol 5, Issue 12, p923
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg1490