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- Title
MicroRNAs: small RNAs with a big role in gene regulation.
- Authors
Lin He; Hannon, Gregory J.
- Abstract
MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a sequence-specific manner. The two founding members of the microRNA family were originally identified in Caenorhabditis elegans as genes that were required for the timed regulation of developmental events. Since then, hundreds of microRNAs have been identified in almost all metazoan genomes, including worms, flies, plants and mammals. MicroRNAs have diverse expression patterns and might regulate various developmental and physiological processes. Their discovery adds a new dimension to our understanding of complex gene regulatory networks.
- Publication
Nature Reviews Genetics, 2004, Vol 5, Issue 7, p522
- ISSN
1471-0056
- Publication type
Academic Journal
- DOI
10.1038/nrg1379