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- Title
Timeline: Z-DNA: the long road to biological function.
- Authors
Rich, Alexander; Zhang, Shuguang
- Abstract
Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a biological role. The most recent data show that some of these proteins participate in the pathology of poxviruses.
- Publication
Nature reviews. Genetics, 2003, Vol 4, Issue 7, p566
- ISSN
1471-0056
- Publication type
Journal Article
- DOI
10.1038/nrg1115