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- Title
Implementing personalized cancer genomics in clinical trials.
- Authors
Simon, Richard; Roychowdhury, Sameek
- Abstract
The recent surge in high-throughput sequencing of cancer genomes has supported an expanding molecular classification of cancer. These studies have identified putative predictive biomarkers signifying aberrant oncogene pathway activation and may provide a rationale for matching patients with molecularly targeted therapies in clinical trials. Here, we discuss some of the challenges of adapting these data for rare cancers or molecular subsets of certain cancers, which will require aligning the availability of investigational agents, rapid turnaround of clinical grade sequencing, molecular eligibility and reconsidering clinical trial design and end points.
- Publication
Nature reviews. Drug discovery, 2013, Vol 12, Issue 5, p358
- ISSN
1474-1784
- Publication type
Journal Article
- DOI
10.1038/nrd3979