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- Title
Targeting the unfolded protein response in disease.
- Authors
Hetz, Claudio; Chevet, Eric; Harding, Heather P
- Abstract
Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a feature of specialized secretory cells and is also observed in many diseases, including cancer, diabetes, autoimmune conditions, liver disorders, obesity and neurodegenerative disorders. Cellular adaptation to ER stress is achieved by the activation of the unfolded protein response, which is an integrated signal transduction pathway that modulates many aspects of ER physiology. When these mechanisms of adaptation are insufficient to handle the unfolded protein load, cells undergo apoptosis. Here, we discuss recent advances in the design of novel compounds and therapeutic strategies to manipulate levels of ER stress in disease.
- Publication
Nature reviews. Drug discovery, 2013, Vol 12, Issue 9, p703
- ISSN
1474-1784
- Publication type
Journal Article
- DOI
10.1038/nrd3976