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- Title
Potential therapeutic uses of BDNF in neurological and psychiatric disorders.
- Authors
Nagahara, Alan H; Tuszynski, Mark H
- Abstract
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease.
- Publication
Nature reviews. Drug discovery, 2011, Vol 10, Issue 3, p209
- ISSN
1474-1784
- Publication type
Journal Article
- DOI
10.1038/nrd3366