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- Title
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets.
- Authors
Konstantinopoulos, Panagiotis A; Karamouzis, Michalis V; Papavassiliou, Athanasios G
- Abstract
The involvement of the RAS superfamily of monomeric GTPases in carcinogenesis is increasingly being appreciated. A complex array of post-translational modifications and a highly sophisticated protein network regulate the spatio-temporal activation of these GTPases. Previous attempts to pharmacologically target this family have focused on the development of farnesyltransferase inhibitors, but the performance of such agents in cancer clinical trials has not been as good as hoped. Here, we review emerging druggable targets and novel therapeutic approaches targeting prenylation and post-prenylation modifications and the functional regulation of GDP/GTP exchange as exciting alternatives for anticancer therapy.
- Publication
Nature reviews. Drug discovery, 2007, Vol 6, Issue 7, p541
- ISSN
1474-1776
- Publication type
Journal Article
- DOI
10.1038/nrd2221