We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Oxygen therapeutics: can we tame haemoglobin?
- Authors
Alayash, Abdu I
- Abstract
Chemically modified or genetically engineered haemoglobins (Hbs) developed as oxygen therapeutics (often termed 'blood substitutes') are designed to correct oxygen deficit due to ischaemia in a variety of clinical settings. These modifications are intended to stabilize Hb outside its natural environment--red blood cells--in a functional tetrameric and/or polymeric form. Uncontrolled haem-mediated oxidative reactions of cell-free Hb and its reactions with various oxidant/antioxidant and cell signalling systems have emerged as an important pathway of toxicity. Current protective strategies designed to produce safe Hb-based products are focused on controlling or suppressing the 'radical' nature of Hb while retaining its oxygen-carrying function.
- Publication
Nature reviews. Drug discovery, 2004, Vol 3, Issue 2, p152
- ISSN
1474-1776
- Publication type
Journal Article
- DOI
10.1038/nrd1307