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- Title
HIF-1 as a target for drug development.
- Authors
Giaccia, Amato; Siim, Bronwyn G; Johnson, Randall S
- Abstract
Sensing and responding to fluxes in oxygen tension is perhaps the single most important variable in physiology, and animal tissues have developed a number of essential mechanisms to cope with the stress of low physiological oxygen levels, or hypoxia. Among these coping mechanisms is the response mediated by the hypoxia-inducible transcription factor, or HIF-1. HIF-1 is an essential component in changing the transcriptional repertoire of tissues as oxygen levels drop, and could prove to be a very important target for drug development, as treatments evolve for diseases, such as cancer, heart disease and stroke, in which hypoxia is a central aspect.
- Publication
Nature reviews. Drug discovery, 2003, Vol 2, Issue 10, p803
- ISSN
1474-1776
- Publication type
Journal Article
- DOI
10.1038/nrd1199