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- Title
The Fanconi anaemia/BRCA pathway.
- Authors
D'Andrea, Alan D; Grompe, Markus
- Abstract
Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability--a common feature of many human cancers.
- Publication
Nature reviews. Cancer, 2003, Vol 3, Issue 1, p23
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc970