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- Title
The retinoblastoma tumour suppressor in development and cancer.
- Authors
Classon, Marie; Harlow, Ed
- Abstract
Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival. To further complicate matters, proteins that are related to RB have redundant as well as antagonistic functions. Recent studies of knockout mice and cells that lack one or more of these proteins have begun to clarify their various context-specific functions and the unique activity of this tumour suppressor.
- Publication
Nature reviews. Cancer, 2002, Vol 2, Issue 12, p910
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc950