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- Title
Molecular basis of the VHL hereditary cancer syndrome.
- Authors
Kaelin, William G, Jr
- Abstract
The von Hippel-Lindau hereditary cancer syndrome was first described about 100 years ago. The unusual clinical features of this disorder predicted a role for the von Hippel-Lindau gene (VHL) in the oxygen-sensing pathway. Indeed, recent studies of this gene have helped to decipher how cells sense changes in oxygen availability, and have revealed a previously unappreciated role of prolyl hydroxylation in intracellular signalling. These studies, in turn, are laying the foundation for the treatment of a diverse set of disorders, including cancer, myocardial infarction and stroke.
- Publication
Nature reviews. Cancer, 2002, Vol 2, Issue 9, p673
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc885