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- Title
Opinion: Histone methyltransferases, diet nutrients and tumour suppressors.
- Authors
Huang, Shi
- Abstract
It is well known that an insufficiency of dietary methyl-group donors can cause cancer, and that a deficiency in methylation is characteristic of cancer, but how carcinogenesis results from abnormal methyl-donor metabolism has long remained a matter of speculation. Recently, however, it has been found that some histone methyltransferases, which require methyl donors for activity, are turnout suppressors. So, how was JUN — the first oncogenic transcription factor — discovered?
- Publication
Nature Reviews Cancer, 2002, Vol 2, Issue 6, p469
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc819