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- Title
O-GlcNAc signalling: implications for cancer cell biology.
- Authors
Slawson, Chad; Hart, Gerald W
- Abstract
O-GlcNAcylation is the covalent attachment of β-D-N-acetylglucosamine (GlcNAc) sugars to serine or threonine residues of nuclear and cytoplasmic proteins, and it is involved in extensive crosstalk with other post-translational modifications, such as phosphorylation. O-GlcNAcylation is becoming increasing realized as having important roles in cancer-relevant processes, such as cell signalling, transcription, cell division, metabolism and cytoskeletal regulation. However, currently little is known about the specific roles of aberrant O-GlcNAcylation in cancer. In this Opinion article, we summarize the current understanding of O-GlcNAcylation in cancer and its emerging functions in transcriptional regulation at the level of chromatin and transcription factors.
- Publication
Nature reviews. Cancer, 2011, Vol 11, Issue 9, p678
- ISSN
1474-1768
- Publication type
Review
- DOI
10.1038/nrc3114