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- Title
Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells.
- Authors
Tyson, John J; Baumann, William T; Chen, Chun; Verdugo, Anael; Tavassoly, Iman; Wang, Yue; Weiner, Louis M; Clarke, Robert
- Abstract
Cancers of the breast and other tissues arise from aberrant decision-making by cells regarding their survival or death, proliferation or quiescence, damage repair or bypass. These decisions are made by molecular signalling networks that process information from outside and from within the breast cancer cell and initiate responses that determine the cell's survival and reproduction. Because the molecular logic of these circuits is difficult to comprehend by intuitive reasoning alone, we present some preliminary mathematical models of the basic decision circuits in breast cancer cells that may aid our understanding of their susceptibility or resistance to endocrine therapy.
- Publication
Nature reviews. Cancer, 2011, Vol 11, Issue 7, p523
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc3081