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- Title
Desmosomes: new perpetrators in tumour suppression.
- Authors
Dusek, Rachel L; Attardi, Laura D
- Abstract
Adherens junctions, which are intercellular adhesive complexes that are crucial for maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour progression. However, the role of desmosomes - adhesion complexes that are related to adherens junctions - in carcinogenesis has remained elusive. Recent studies using mouse genetic approaches have uncovered a role for desmosomes in tumour suppression, demonstrating that desmosome downregulation occurs before that of adherens junctions to drive tumour development and early invasion, suggesting a two-step model of adhesion dysfunction in cancer progression.
- Publication
Nature reviews. Cancer, 2011, Vol 11, Issue 5, p317
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc3051