We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.
- Authors
Morris, John P, 4th; Wang, Sam C; Hebrok, Matthias
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in KRAS and frequent deregulation of crucial embryonic signalling pathways, including the Hedgehog (Hh) and Wnt-β-catenin cascades. The creation of mouse models that closely resemble the human disease has provided a platform to better understand when and in which cell types these pathways are misregulated during PDAC development. Here we examine the central part that KRAS plays in the biology of PDAC, and how the timing and location of Hh and Wnt-β-catenin signalling dictate the specification and oncogenic properties of PDAC.
- Publication
Nature reviews. Cancer, 2010, Vol 10, Issue 10, p683
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2899