We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.
- Authors
Ping Chi; Allis, C. David; Wang, Gang Greg; Chi, Ping
- Abstract
Post-translational modification of histones provides an important regulatory platform for processes such as gene transcription and DNA damage repair. It has become increasingly apparent that the misregulation of histone modification, which is caused by the deregulation of factors that mediate the modification installation, removal and/or interpretation, actively contributes to human cancer. In this Review, we summarize recent advances in understanding the interpretation of certain histone methylations by plant homeodomain finger-containing proteins, and how misreading, miswriting and mis-erasing of histone methylation marks can be associated with oncogenesis and progression. These observations provide us with a greater mechanistic understanding of epigenetic alterations in human cancers and might also help direct new therapeutic interventions in the future.
- Publication
Nature Reviews Cancer, 2010, Vol 10, Issue 7, p457
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc2876