We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Eph receptors and ephrins in cancer: bidirectional signalling and beyond.
- Authors
Pasquale, Elena B
- Abstract
The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression. Eph gene mutations probably also contribute to cancer pathogenesis. Eph receptors and ephrins have been shown to affect the growth, migration and invasion of cancer cells in culture as well as tumour growth, invasiveness, angiogenesis and metastasis in vivo. However, Eph signalling activities in cancer seem to be complex, and are characterized by puzzling dichotomies. Nevertheless, the Eph receptors are promising new therapeutic targets in cancer.
- Publication
Nature reviews. Cancer, 2010, Vol 10, Issue 3, p165
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2806