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- Title
Fibroblast growth factor signalling: from development to cancer.
- Authors
Turner, Nicholas; Grose, Richard
- Abstract
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological functions, regulating cellular proliferation, survival, migration and differentiation. Although targeting FGF signalling as a cancer therapeutic target has lagged behind that of other receptor tyrosine kinases, there is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed. Although FGF signalling can drive tumorigenesis, in different contexts FGF signalling can mediate tumour protective functions; the identification of the mechanisms that underlie these differential effects will be important to understand how FGF signalling can be most appropriately therapeutically targeted.
- Publication
Nature reviews. Cancer, 2010, Vol 10, Issue 2, p116
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2780