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- Title
Senescence in tumours: evidence from mice and humans.
- Authors
Collado, Manuel; Serrano, Manuel
- Abstract
The importance of cellular senescence, which is a stress response that stably blocks proliferation, is increasingly being recognized. Senescence is prevalent in pre-malignant tumours, and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence owing to interventions that restore tumour suppressor function or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells, which may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, which may partly underlie its therapeutic activity. Although these concepts are well supported in mouse models, translating them to clinical oncology remains a challenge.
- Publication
Nature reviews. Cancer, 2010, Vol 10, Issue 1, p51
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2772