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- Title
p53 ancestry: gazing through an evolutionary lens.
- Authors
Wan-Jin Lu; Amatruda, James F.; Abrams, John M.; Lu, Wan-Jin
- Abstract
Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?
- Publication
Nature Reviews Cancer, 2009, Vol 9, Issue 10, p758
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc2732