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- Title
p21 in cancer: intricate networks and multiple activities.
- Authors
Abbas, Tarek; Dutta, Anindya
- Abstract
One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals. This Review focuses on recent advances in our understanding of the regulation of p21 and its biological functions with emphasis on its p53-independent tumour suppressor activities and paradoxical tumour-promoting activities, and their implications in cancer.
- Publication
Nature reviews. Cancer, 2009, Vol 9, Issue 6, p400
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2657