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- Title
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics.
- Authors
Cragg, Mark S; Harris, Claire; Strasser, Andreas; Scott, Clare L
- Abstract
Therapeutic targeting of tumours on the basis of molecular analysis is a new paradigm for cancer treatment but has yet to fulfil expectations. For many solid tumours, targeted therapeutics, such as inhibitors of oncogenic kinase pathways, elicit predominantly disease-stabilizing, cytostatic responses, rather than tumour regression. Combining oncogenic kinase inhibitors with direct activators of the apoptosis machinery, such as the BH3 mimetic ABT-737, may unlock potent anti-tumour potential to produce durable clinical responses with less collateral damage.
- Publication
Nature reviews. Cancer, 2009, Vol 9, Issue 5, p321
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2615