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- Title
Basal cell carcinomas: attack of the hedgehog.
- Authors
Epstein, Ervin H
- Abstract
Basal cell carcinomas (BCCs) were essentially a molecular 'black box' until some 12 years ago, when identification of a genetic flaw in a rare subset of patients who have a great propensity to develop BCCs pointed to aberrant Hedgehog signalling as the pivotal defect leading to formation of these tumours. This discovery has facilitated a remarkable increase in our understanding of BCC carcinogenesis and has highlighted the carcinogenic role of this developmental pathway when aberrantly activated in adulthood. Importantly, a phase 1 first-in-human trial of a Hedgehog inhibitor has shown real progress in halting and even reversing the growth of these tumours.
- Publication
Nature reviews. Cancer, 2008, Vol 8, Issue 10, p743
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2503