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- Title
Hypoxia signalling through mTOR and the unfolded protein response in cancer.
- Authors
Wouters, Bradly G; Koritzinsky, Marianne
- Abstract
Hypoxia occurs in the majority of tumours, promoting angiogenesis, metastasis and resistance to therapy. Responses to hypoxia are orchestrated in part through activation of the hypoxia-inducible factor family of transcription factors (HIFs). Recently, two additional O(2)-sensitive signalling pathways have also been implicated: signalling through the mammalian target of rapamycin (mTOR) kinase and signalling through activation of the unfolded protein response (UPR). Although they are activated independently, growing evidence suggests that HIF-, mTOR- and UPR-dependent responses to hypoxia act in an integrated way, influencing each other and common downstream pathways that affect gene expression, metabolism, cell survival, tumorigenesis and tumour growth.
- Publication
Nature reviews. Cancer, 2008, Vol 8, Issue 11, p851
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2501