We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Targeting the oncogene and kinome chaperone CDC37.
- Authors
Gray, Phillip J, Jr; Prince, Thomas; Cheng, Jinrong; Stevenson, Mary Ann; Calderwood, Stuart K
- Abstract
CDC37 is a molecular chaperone that physically stabilizes the catalytic domains found in protein kinases and is therefore a wide-spectrum regulator of protein phosphorylation. It is also an overexpressed oncoprotein that mediates carcinogenesis by stabilizing the compromised structures of mutant and/or overexpressed oncogenic kinases. Recent work shows that such dependency of malignant cells on increased CDC37 expression is a vulnerability that can be targeted in cancer by agents that deplete or inhibit CDC37. CDC37 is thus a candidate for broad-spectrum molecular cancer therapy.
- Publication
Nature reviews. Cancer, 2008, Vol 8, Issue 7, p491
- ISSN
1474-1768
- Publication type
Review
- DOI
10.1038/nrc2420