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- Title
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis.
- Authors
Pawelek, John M; Chakraborty, Ashok K
- Abstract
The causes of metastasis remain elusive despite vast information on cancer cells. We posit that cancer cell fusion with macrophages or other migratory bone marrow-derived cells (BMDCs) provides an explanation. BMDC-tumour hybrids have been detected in numerous animal models and recently in human cancer. Molecular studies indicate that gene expression in such hybrids reflects a metastatic phenotype. Should BMDC-tumour fusion be found to underlie invasion and metastasis in human cancer, new approaches for therapy would surely follow.
- Publication
Nature reviews. Cancer, 2008, Vol 8, Issue 5, p377
- ISSN
1474-1768
- Publication type
Review
- DOI
10.1038/nrc2371