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- Title
Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy.
- Authors
Colombo, Mario P; Piconese, Silvia
- Abstract
Tumour-induced expansion of regulatory T (T(Reg)) cells is an obstacle to successful cancer immunotherapy. The potential benefit of T(Reg)-cell depletion through the interleukin-2 receptor is lost by the concurrent elimination of activated effector lymphocytes and possibly by the de novo induction of T(Reg)-cell replenishment. In theory, the functional inactivation of T(Reg) cells will maintain them at high numbers in tumours and avoid their replenishment from the peripheral lymphocyte pool, which has the capacity to further suppress the effector lymphocyte anti-tumour response.
- Publication
Nature reviews. Cancer, 2007, Vol 7, Issue 11, p880
- ISSN
1474-1768
- Publication type
Review
- DOI
10.1038/nrc2250