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- Title
microRNAs join the p53 network--another piece in the tumour-suppression puzzle.
- Authors
He, Lin; He, Xingyue; Lowe, Scott W; Hannon, Gregory J
- Abstract
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
- Publication
Nature reviews. Cancer, 2007, Vol 7, Issue 11, p819
- ISSN
1474-1768
- Publication type
Review
- DOI
10.1038/nrc2232