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- Title
The emerging roles of forkhead box (Fox) proteins in cancer.
- Authors
Myatt, Stephen S; Lam, Eric W-F
- Abstract
Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss the evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer, and evaluate the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses.
- Publication
Nature reviews. Cancer, 2007, Vol 7, Issue 11, p847
- ISSN
1474-1768
- Publication type
Journal Article
- DOI
10.1038/nrc2223