We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyperactive Ras in developmental disorders and cancer.
- Authors
Schubbert, Suzanne; Shannon, Kevin; Bollag, Gideon
- Abstract
Ras genes are the most common targets for somatic gain-of-function mutations in human cancer. Recently, germline mutations that affect components of the Ras-Raf-mitogen-activated and extracellular-signal regulated kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) pathway were shown to cause several developmental disorders, including Noonan, Costello and cardio-facio-cutaneous syndromes. Many of these mutant alleles encode proteins with aberrant biochemical and functional properties. Here we will discuss the implications of germline mutations in the Ras-Raf-MEK-ERK pathway for understanding normal developmental processes and cancer pathogenesis.
- Publication
Nature reviews. Cancer, 2007, Vol 7, Issue 4, p295
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc2109