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- Title
MicroRNA signatures in human cancers.
- Authors
Calin, George A; Croce, Carlo M
- Abstract
MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
- Publication
Nature reviews. Cancer, 2006, Vol 6, Issue 11, p857
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1997