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- Title
Lineage dependency and lineage-survival oncogenes in human cancer.
- Authors
Garraway, Levi A; Sellers, William R
- Abstract
Although cell-lineage and differentiation models dominate tumour classification and treatment, the recognition that cancer is also a genomic disease has prompted a reconfiguration of cancer taxonomies according to molecular criteria. Recent evidence indicates that a synthesis of lineage-based and genetic paradigms might offer new insights into crucial and therapeutically pliable tumour dependencies. For example, MITF (microphthalmia-associated transcription factor), which is a master regulator of the melanocyte lineage, might become a melanoma oncogene when deregulated in certain genetic contexts. MITF and other lineage-survival genes therefore implicate lineage dependency (or lineage addiction) as a newly recognized mechanism that is affected by tumour genetic alterations.
- Publication
Nature reviews. Cancer, 2006, Vol 6, Issue 8, p593
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1947