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- Title
Photodynamic therapy and anti-tumour immunity.
- Authors
Castano, Ana P; Mroz, Pawel; Hamblin, Michael R
- Abstract
Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.
- Publication
Nature reviews. Cancer, 2006, Vol 6, Issue 7, p535
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1894