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- Title
Evolving concepts in the pathogenesis of hairy-cell leukaemia.
- Authors
Tiacci, Enrico; Liso, Arcangelo; Piris, Miguel; Falini, Brunangelo
- Abstract
Hairy-cell leukaemia (HCL) has long been recognized as distinct from other chronic B-cell malignancies, but several questions remain unanswered. What is the HCL cell of origin? Why does HCL lack the hallmarks of most mature B-cell tumours (for example, chromosomal translocations and consistent lymph node involvement) and show unique features like 'hairy' morphology and bone-marrow fibrosis? Gene-expression profiling and other studies have recently provided new insights into HCL biology and have the potential to affect clinical practice.
- Publication
Nature reviews. Cancer, 2006, Vol 6, Issue 6, p437
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1888