We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mapping normal and cancer cell signalling networks: towards single-cell proteomics.
- Authors
Irish, Jonathan M; Kotecha, Nikesh; Nolan, Garry P
- Abstract
Oncogenesis and tumour progression are supported by alterations in cell signalling. Using flow cytometry, it is now possible to track and analyse signalling events in individual cancer cells. Data from this type of analysis can be used to create a network map of signalling in each cell and to link specific signalling profiles with clinical outcomes. This form of 'single-cell proteomics' can identify pathways that are activated in therapy-resistant cells and can provide biomarkers for cancer diagnosis and for determining patient prognosis.
- Publication
Nature reviews. Cancer, 2006, Vol 6, Issue 2, p146
- ISSN
1474-175X
- Publication type
Review
- DOI
10.1038/nrc1804