We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Oncogenic PI3K deregulates transcription and translation.
- Authors
Bader, Andreas G; Kang, Sohye; Zhao, Li; Vogt, Peter K
- Abstract
There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer pathogenesis. Experimental data document a requirement for deregulation of both transcription and translation in PI3K-mediated oncogenic transformation. The recent discoveries of cancer-specific mutations in PIK3CA, the gene that encodes the catalytic subunit p110alpha of PI3K, have heightened the interest in the oncogenic potential of this lipid kinase and have made p110alpha an ideal drug target.
- Publication
Nature reviews. Cancer, 2005, Vol 5, Issue 12, p921
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1753