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- Title
Radiation and the microenvironment - tumorigenesis and therapy.
- Authors
Barcellos-Hoff, Mary Helen; Park, Catherine; Wright, Eric G
- Abstract
Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.
- Publication
Nature reviews. Cancer, 2005, Vol 5, Issue 11, p867
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1735