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- Title
The role of disturbed pH dynamics and the Na<sup>+</sup>/H<sup>+</sup> exchanger in metastasis.
- Authors
Cardone, Rosa A.; Casavola, Valeria; Reshkin, Stephan J.
- Abstract
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na+/H+ exchanger NHE1 and the H+/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia — cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?
- Publication
Nature Reviews Cancer, 2005, Vol 5, Issue 10, p786
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc1713