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- Title
Opinion: Post-prenylation-processing enzymes as new targets in oncogenesis.
- Authors
Winter-Vann, Ann M.; Casey, Patrick J.
- Abstract
RAS and many other oncogenic proteins undergo a complex series of post-translational modifications that are initiated by the addition of an isoprenoid lipid through a process known as prenylation. Following prenylation, these proteins usually undergo endoproteolytic processing by the RCE1 protease and then carboxyl methylation by a unique methyltransferase known as isoprenylcysteine carboxyl methyltransferase (ICMT). Although inhibitors that have been designed to target the prenylation step are now in advanced-stage clinical trials, their utility and efficacy seem to be limited. Recent findings, however, indicate that the inhibition of these post-prenylation-processing steps-particularly that of ICMT-catalysed methylation-might provide a better approach to the control of cancer-cell proliferation.
- Publication
Nature Reviews Cancer, 2005, Vol 5, Issue 5, p405
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc1612