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- Title
Tumour stem cells and drug resistance.
- Authors
Dean, Michael; Fojo, Tito; Bates, Susan
- Abstract
The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents. Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies.
- Publication
Nature reviews. Cancer, 2005, Vol 5, Issue 4, p275
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1590