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- Title
Control of DNA replication and its potential clinical exploitation.
- Authors
Gonzalez, Michael A; Tachibana, Kiku-e K; Laskey, Ronald A; Coleman, Nicholas
- Abstract
Multiple conserved mechanisms limit DNA replication to once per cell cycle. One vital level of control focuses on the loading of the heterohexameric ring of minichromosome maintenance proteins (MCMs) onto chromatin in the hierarchical assembly of the pre-replication complex at origins of replication. An essential role in proliferation for MCMs and their regulators makes them potentially important biomarkers for routine clinical use in cancer detection and prognosis.
- Publication
Nature reviews. Cancer, 2005, Vol 5, Issue 2, p135
- ISSN
1474-175X
- Publication type
Review
- DOI
10.1038/nrc1548