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- Title
Polyamines and cancer: old molecules, new understanding.
- Authors
Gerner, Eugene W; Meyskens, Frank L, Jr
- Abstract
The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues.
- Publication
Nature reviews. Cancer, 2004, Vol 4, Issue 10, p781
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1454