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- Title
Transcription - guarding the genome by sensing DNA damage.
- Authors
Ljungman, Mats; Lane, David P
- Abstract
Cells induce the expression of DNA-repair enzymes, activate cell-cycle checkpoints and, under some circumstances, undergo apoptosis in response to DNA-damaging agents. The mechanisms by which these cellular responses are triggered are not well understood, but there is recent evidence that the transcription machinery might be used in DNA-damage surveillance and in triggering DNA-damage responses to suppress mutagenesis. Transcription might also act as a DNA-damage dosimeter where the severity of blockage determines whether or not to induce cell death. Could transcription therefore be a potential therapeutic target for anticancer strategies?
- Publication
Nature reviews. Cancer, 2004, Vol 4, Issue 9, p727
- ISSN
1474-175X
- Publication type
Review
- DOI
10.1038/nrc1435