We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dynamics of cancer progression.
- Authors
Franziska Michor; Yoh Iwasa; Martin A.Nowak, Jiri
- Abstract
Evolutionary concepts such as mutation and selection can be best described when formulated as mathematical equations. Cancer arises as a consequence of somatic evolution. Therefore, a mathematical approach can be used to understand the process of cancer initiation and progression. But what are the fundamental principles that govern the dynamics of activating oncogenes and inactivating tumour-suppressor genes in populations of reproducing cells? Also, how does a quantitative theory of somatic mutation and selection help us to evaluate the role of genetic instability?
- Publication
Nature Reviews Cancer, 2004, Vol 4, Issue 3, p197
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc1295