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- Title
HEDGEHOG SIGNALLING IN CANCER FORMATION AND MAINTENANCE.
- Authors
di Magliano, Marina Pasca; Hebrok, Matthias
- Abstract
• Hedgehog (HH) signaling is required for cell differentiation and organ formation during embryogenesis. In the adult, HH signaling remains active in some organs where it has been implicated in the regulation of stem-cell maintenance and proliferation. • HH signaling targets include genes that are important for cell proliferation — protooncogenes — as well as growth factors. • Misregulation of HH signaling has been shown to cause formation of basal-cell carcinoma and medulloblastoma, and mutations of HH pathway components have been found both in familial and sporadic cases. More recently, small-cell lung cancer (SCLC) and pancreatic adenocarcinoma have been linked to HH signaling, providing a molecular mechanism for these aggressive diseases. • Importantly, HH signaling seems to be required not only for cancer initiation but also for tumor growth and survival of medulloblastomas, SCLC and pancreatic adenocarcinoma. • HH inhibitors could provide novel therapeutic approaches for treatment of otherwise hard to cure cancer types. Synthetic compounds have been identified that act as HH inhibitors in a very specific manner. INSET: Summary.
- Publication
Nature Reviews Cancer, 2003, Vol 3, Issue 12, p903
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc1229