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- Title
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
- Authors
Radtke, Freddy; Raj, Kenneth
- Abstract
Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.
- Publication
Nature reviews. Cancer, 2003, Vol 3, Issue 10, p756
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1186