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- Title
The emerging role of lysophosphatidic acid in cancer.
- Authors
Mills, Gordon B; Moolenaar, Wouter H
- Abstract
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
- Publication
Nature reviews. Cancer, 2003, Vol 3, Issue 8, p582
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1143