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- Title
Stem-cell hierarchy in skin cancer.
- Authors
Perez-Losada, Jesus; Balmain, Allan
- Abstract
Tumour architecture mimics many of the features of normal tissues, with a cellular hierarchy that regulates the balance between cell renewal and cell death. Although many tumours contain cells with the characteristics of stem cells, the identity of the normal cells that acquire the first genetic hits leading to initiation of carcinogenesis has remained elusive. Identification of the primary cell of origin of cancers and the mechanisms that influence cell-fate decisions will be crucial for the development of novel non-toxic therapies that influence tumour-cell behaviour.
- Publication
Nature reviews. Cancer, 2003, Vol 3, Issue 6, p434
- ISSN
1474-175X
- Publication type
Journal Article
- DOI
10.1038/nrc1095